RESUMO
Up to now, hundreds of human blood groups have been detected globally, but none have been found in the Chinese population. China is a multi-ethnic country with rich genetic polymorphism and variation. The Chinese pangenome reference reveals that the Chinese carry some genetic variations that are different from other ethnic groups in the world, especially the discovery of approximately 5 million new base pair sequences, which are considered the core genome sequences of the Chinese population. Research on red blood cell membrane proteomics has shown that red blood cells carry over 2 600 kinds of erythrocyte membrane proteins, and currently only 37 protein molecules have detected blood group antigens. The above data suggest that the possibility of new blood group in the Chinese population cannot be ruled out. This comment describes the history of the discovery of blood groups and the challenges faced by Chinese scholars.